Title : Prior exposure of pancreatic tumors to [sorafenib + vorinostat] enhances the efficacy of an anti-PD-1 antibody.

Pub. Date : 2019

PMID : 30142009






2 Functional Relationships(s)
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1 Exposure to [sorafenib + vorinostat] reduced the expression of beta-catenin, ERBB1, BCL-XL and MCL-1, and the phosphorylation of AKT T308, AKT S473, GSK3 S9/21, mTORC1 and mTORC2. Sorafenib AKT serine/threonine kinase 1 Homo sapiens
2 Exposure to [sorafenib + vorinostat] reduced the expression of beta-catenin, ERBB1, BCL-XL and MCL-1, and the phosphorylation of AKT T308, AKT S473, GSK3 S9/21, mTORC1 and mTORC2. Sorafenib AKT serine/threonine kinase 1 Homo sapiens