Title : Effect of Combined Sorafenib/Cisplatinum Treatment on the Autophagy and Proliferation of Hepatocellular Carcinoma hepG2 Cells in Vitro.

Pub. Date : 2020 Oct 1

PMID : 33112540






2 Functional Relationships(s)
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1 qPCR and western blot revealed that a combination of Sorafenib (10 mumol/L) and cisplatinum (10 mg/L) reduced the transcription and protein expression of autophagy-related AKT and mTOR but increased that of LC3 (P <0.05). Sorafenib AKT serine/threonine kinase 1 Homo sapiens
2 CONCLUSION: Combining Sorafenib and cisplatinum can effectively induce cell autophagy and reduce cellular proliferation via the PI3K/AKT/mTOR signal pathway.<br />. Sorafenib AKT serine/threonine kinase 1 Homo sapiens