Pub. Date : 2021 Jul 28
PMID : 34366628
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, KEGG pathway enrichment analysis of DGE-seq demonstrated that the phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was essential for the sorafenib resistance induced by YB-1. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Finally, YB-1 suppressed the inactivation of the PI3K/Akt signaling pathway induced by sorafenib, and the blockade of the PI3K/Akt signaling pathway by LY294002 mitigated YB-1-induced sorafenib resistance. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |