Title : Y-Box Binding Protein-1 Promotes Epithelial-Mesenchymal Transition in Sorafenib-Resistant Hepatocellular Carcinoma Cells.

Pub. Date : 2020 Dec 28

PMID : 33379356






2 Functional Relationships(s)
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Protein Name
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1 Phosphoinositide-3-kinase (PI3K) and protein kinase B (AKT) were activated by sorafenib, which, in turn, increased the phosphorylation level of YB-1. Sorafenib AKT serine/threonine kinase 1 Homo sapiens
2 Our collective findings suggest that sorafenib promotes YB-1 phosphorylation through effect from the EGFR/PI3K/AKT pathway, leading to significant enhancement of hepatocellular carcinoma (HCC) cell metastasis. Sorafenib AKT serine/threonine kinase 1 Homo sapiens