Dexamethasone

AKT serine/threonine kinase 1 ; Homo sapiens







79 Article(s)
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1 35281469 Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling. 2022 1
2 33236136 LINC00473 rescues human bone marrow mesenchymal stem cells from apoptosis induced by dexamethasone through the PEBP1‑mediated Akt/Bad/Bcl‑2 signaling pathway. 2021 Jan 3
3 33360972 Human macrophages stimulate expression of inflammatory mediators in adipocytes; effects of second-generation antipsychotics and glucocorticoids on cellular cross-talk. 2021 Mar 1
4 33549034 Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway. 2021 Feb 6 4
5 33838126 Glucocorticoids suppressed osteoblast differentiation by decreasing Sema3A expression via the PIK3/Akt pathway. 2021 Jun 1 2
6 33853677 Classical isoforms of protein kinase C (PKC) and Akt regulate the osteogenic differentiation of human dental follicle cells via both β-catenin and NF-κB. 2021 Apr 14 1
7 34152396 Direct P70S6K1 inhibition to replace dexamethasone in synergistic combination with MCL-1 inhibition in multiple myeloma. 2021 Jun 22 1
8 34399087 Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells. 2021 Oct 2
9 34537816 Trimetazidine attenuates dexamethasone-induced muscle atrophy via inhibiting NLRP3/GSDMD pathway-mediated pyroptosis. 2021 Sep 18 2
10 34803488 Long term usage of dexamethasone accelerating accelerates the initiation of osteoarthritis via enhancing chondrocyte apoptosis and the extracellular matrix calcification and apoptosis of chondrocytes. 2021 1
11 31751158 Reduced NGF Level Promotes Epithelial-Mesenchymal Transition in Human Lens Epithelial Cells Exposed to High Dexamethasone Concentrations. 2020 Jun 2
12 31853327 Dexamethasone and lenvatinib inhibit migration and invasion of non-small cell lung cancer by regulating EKR/AKT and VEGF signal pathways. 2020 Jan 3
13 32269608 Theophylline and dexamethasone in combination reduce inflammation and prevent the decrease in HDAC2 expression seen in monocytes exposed to cigarette smoke extract. 2020 May 4
14 32272509 Dexamethasone Interferes with Autophagy and Affects Cell Survival in Irradiated Malignant Glioma Cells. 2020 Sep 1
15 32404561 Involvement of claudin-5 in H2S-induced acute lung injury. 2020 1
16 32546661 A Novel Approach to Safer Glucocorticoid Receptor-Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition. 2020 Sep 1
17 32771037 Apolipoprotein D alleviates glucocorticoid-induced osteogenesis suppression in bone marrow mesenchymal stem cells via the PI3K/Akt pathway. 2020 Aug 8 1
18 32796067 Specific Akt Family Members Impair Stress-Mediated Transactivation of Viral Promoters and Enhance Neuronal Differentiation: Important Functions for Maintaining Latency. 2020 Oct 14 1
19 32989221 Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness. 2020 Sep 23 1
20 30598523 Akt2 mediates glucocorticoid resistance in lymphoid malignancies through FoxO3a/Bim axis and serves as a direct target for resistance reversal. 2019 Jan 1 3
21 31083497 Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes. 2019 May 11 1
22 31328390 Glucocorticoid receptor inhibits Müller glial galectin-1 expression via DUSP1-dependent and -independent deactivation of AP-1 signalling. 2019 Oct 1
23 30004470 MicroRNA-106a-5p Inhibited C2C12 Myogenesis via Targeting PIK3R1 and Modulating the PI3K/AKT Signaling. 2018 Jul 2 2
24 30025893 Glucocorticoid-induced CREB activation and myostatin expression in C2C12 myotubes involves phosphodiesterase-3/4 signaling. 2018 Sep 10 1
25 27649272 Heat Stress Modulates Both Anabolic and Catabolic Signaling Pathways Preventing Dexamethasone-Induced Muscle Atrophy In Vitro. 2017 Mar 1
26 28529032 Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis. 2017 Jun 1
27 28825630 Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone. 2017 Aug 19 2
28 28946211 Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes. 2017 Nov 2
29 29021711 Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth. 2017 Oct 1
30 29059216 Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters. 2017 1
31 29263916 Overexpression of CIP2A is associated with poor prognosis in multiple myeloma. 2017 1
32 26080839 Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235. 2016 Feb 1 3
33 26693911 Dexamethasone Inhibits TGF-β1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61. 2016 Jul 4
34 26845432 miR-137 Suppresses the Phosphorylation of AKT and Improves the Dexamethasone Sensitivity in Multiple Myeloma Cells Via Targeting MITF. 2016 1
35 27151574 The pro-adhesive and pro-survival effects of glucocorticoid in human ovarian cancer cells. 2016 Jul 2
36 27187377 Pigment Epithelium-Derived Factor (PEDF) Protects Osteoblastic Cell Line from Glucocorticoid-Induced Apoptosis via PEDF-R. 2016 May 13 1
37 25753754 Fluocinolone Acetonide Is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. 2015 Sep 1
38 25778879 Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells. 2015 1
39 25957293 Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression. 2015 Jul 15 2
40 26101183 Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. 2015 Aug 3
41 26165503 Autophagy protects chondrocytes from glucocorticoids-induced apoptosis via ROS/Akt/FOXO3 signaling. 2015 Dec 4
42 26206089 miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K/AKT pathway. 2015 Dec 1
43 25185805 Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. 2014 Nov 15 1
44 25556455 Dexamethasone disrupts cytoskeleton organization and migration of T47D Human breast cancer cells by modulating the AKT/mTOR/RhoA pathway. 2014 3
45 23426970 Dexamethasone induces caveolin-1 in vascular endothelial cells: implications for attenuated responses to VEGF. 2013 Apr 15 1
46 23710442 Dexamethasone inhibits podocyte apoptosis by stabilizing the PI3K/Akt signal pathway. 2013 4
47 21840619 IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K/Akt pathway. 2012 Jan 1
48 22183914 Activation of Akt is associated with poor prognosis and chemotherapeutic resistance in pediatric B-precursor acute lymphoblastic leukemia. 2012 Jul 15 1
49 22223069 FOXO1 involvement in insulin resistance-related pro-inflammatory cytokine production in hepatocytes. 2012 Apr 1
50 22536436 Tau phosphorylation and μ-calpain activation mediate the dexamethasone-induced inhibition on the insulin-stimulated Akt phosphorylation. 2012 1