Pub. Date : 2016 Jul
PMID : 26693911
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone Inhibits TGF-beta1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Alternatively, both migratory pathways, expression of AKT and ERK, and the target factor CYR61 was also tested by co-treatment with TGF-beta1 and dexamethasone. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | ERK and AKT signaling pathways were found to mediate TGF-beta1-induced migration, which was inhibited by dexamethasone. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | CONCLUSION: These findings suggested that dexamethasone inhibits AKT and ERK phosphorylation, leading to decreased CYR61 expression, which in turn blocks TGF-beta1-induced migration. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |