Title : LINC00473 rescues human bone marrow mesenchymal stem cells from apoptosis induced by dexamethasone through the PEBP1‑mediated Akt/Bad/Bcl‑2 signaling pathway.

Pub. Date : 2021 Jan

PMID : 33236136






3 Functional Relationships(s)
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1 LINC00473 rescues human bone marrow mesenchymal stem cells from apoptosis induced by dexamethasone through the PEBP1-mediated Akt/Bad/Bcl-2 signaling pathway. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens
2 In further experiments, it was found that the upregulation of LINC00473 markedly promoted the phosphorylation of Akt in Dex-stimulated hBMSCs, and increased the protein level of phosphatidylethanolamine-binding protein 1 (PEBP1). Dexamethasone AKT serine/threonine kinase 1 Homo sapiens
3 Furthermore, the upregulation of PEBP1 triggered a marked increase in the levels of Akt phosphorylation in Dex-stimulated hBMSCs, which was line with the upregulation of LINC00473. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens