Pub. Date : 2013
PMID : 23710442
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone inhibits podocyte apoptosis by stabilizing the PI3K/Akt signal pathway. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In contrast, DEX restores CD2AP-PI3K-Akt-GSK3 beta signaling, which promotes the activity of antiapoptotic proteins and inhibits the activity of proapoptotic proteins. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | DEX treatment induced a concentration-dependent reversal of PAN-induced p-Akt and p-GSK3 beta downregulation. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These results strongly suggest that DEX protects podocytes by stabilizing the expression and subcellular distribution of CD2AP and by maintaining the expression of phosphor-activated Akt and GSK3beta . | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |