Pub. Date : 2015 Dec
PMID : 26165503
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | THE RESULTS: Dex increased intracellular ROS level, the expression of Akt, FOXO3 as well as autophagy flux in human chondrocytes. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Catalase, the ROS scavenger, suppressed Dex-induced up-regulation of autophagy flux and expression of aggrecanases and Akt. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | MK-2206 and LY294002, the PI3K/Akt inhibitors, repressed Dex-induced up-regulation of FOXO3. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Autophagy was induced in response to Dex-induced up-regulation of ROS via ROS/Akt/FOXO3 signal pathway. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |