Title : Akt2 mediates glucocorticoid resistance in lymphoid malignancies through FoxO3a/Bim axis and serves as a direct target for resistance reversal.

Pub. Date : 2019 Jan 1

PMID : 30598523






3 Functional Relationships(s)
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1 Here, we found T-acute lymphoblastic leukemia (T-ALL) cells acquire resistance to dexamethasone (DEX)-mediated killing through abnormal activation of Akt, resulting in inhibition of the FoxO3a/Bim pathway. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens
2 Here, we found T-acute lymphoblastic leukemia (T-ALL) cells acquire resistance to dexamethasone (DEX)-mediated killing through abnormal activation of Akt, resulting in inhibition of the FoxO3a/Bim pathway. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens
3 Inhibition of Akt is most effective at restoring sensitivity to DEX of GC-resistant lymphocytes in vitro and in vivo, but shows significant hepatotoxicity in vivo. Dexamethasone AKT serine/threonine kinase 1 Homo sapiens