Pub. Date : 2021 Feb 6
PMID : 33549034
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Diallyl thiosulfinate enhanced the anti-cancer activity of dexamethasone in the side population cells of multiple myeloma by promoting miR-127-3p and deactivating the PI3K/AKT signaling pathway. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, the combination of DATS+Dex promoted miR-127-3p expression and inhibited PI3K, p-AKT, and p-mTOR expression in SP cells. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Additionally, knockdown of miR-127-3p activated the PI3K/AKT/mTOR signaling pathway in MM SP cells cotreated with DATS+Dex. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | CONCLUSION: We demonstrated that cotreatment with DATS+Dex reduced cell proliferation, promoted apoptosis, and caused cell cycle arrest of MM SP cells by promoting miR-127-3p expression and deactivating the PI3K/AKT/mTOR signaling pathway. | Dexamethasone | AKT serine/threonine kinase 1 | Homo sapiens |