Arsenic Trioxide

tumor protein p53 ; Homo sapiens







66 Article(s)
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1 34800879 Novel combination therapy of prostate cancer cells with arsenic trioxide and flutamide: An in-vitro study. 2022 Feb 1
2 35487055 Human prostate cancer cell epithelial-to-mesenchymal transition as a novel target of arsenic trioxide and curcumin therapeutic approach. 2022 Jun 1
3 33357454 Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. 2021 Feb 8 3
4 33508133 Broad-spectrum rescue compounds for structural p53 mutations: perspective on 'Arsenic trioxide rescues structural p53 mutations through a cryptic allosteric site'. 2021 May 7 2
5 33561393 Arsenic and an Old Place: Rescuing p53 Mutants in Cancer. 2021 Feb 8 1
6 34255251 Effects of co-administration of arsenic trioxide and Schiff base oxovanadium complex on the induction of apoptosis in acute promyelocytic leukemia cells. 2021 Oct 1
7 34476069 Arsenic trioxide targets Hsp60, triggering degradation of p53 and survivin. 2021 Aug 18 3
8 34880920 Exploring the Mechanisms of Arsenic Trioxide (Pishuang) in Hepatocellular Carcinoma Based on Network Pharmacology. 2021 1
9 32017938 Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression. 2020 Apr 5 8
10 29535630 Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology. 2018 1
11 29910624 Effects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1. 2018 1
12 29164574 Mechanism of As2O3 induces apoptosis of glioma U87 cells. 2017 Nov 1
13 26440706 p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study. 2016 Jan 1
14 27638049 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. 2016 Nov 1 2
15 25444910 Arsenic trioxide amplifies cisplatin toxicity in human tubular cells transformed by HPV-16 E6/E7 for further therapeutic directions in renal cell carcinoma. 2015 Jan 28 1
16 23255470 Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic. 2014 May 2
17 24399651 The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma. 2014 May 9
18 24738333 Antitumor efficacy of DMSA modified Fe3O4 magnetic nanoparticles combined with arsenic trioxide and adriamycin in Raji cells. 2014 Feb 1
19 24833880 Arsenic trioxide induces apoptosis of human gastrointestinal cancer cells. 2014 May 14 1
20 24884809 Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma. 2014 May 31 4
21 24927258 Increased growth-inhibitory and cytotoxic activity of arsenic trioxide in head and neck carcinoma cells with functional p53 deficiency and resistance to EGFR blockade. 2014 9
22 25116336 Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase. 2014 6
23 25485499 Proteasome inhibitors suppress the protein expression of mutant p53. 2014 1
24 26579413 ETME, a novel β-elemene derivative, synergizes with arsenic trioxide in inducing apoptosis and cell cycle arrest in hepatocarcinoma cells via a p53-dependent pathway. 2014 Dec 1
25 23337567 Osteoblasts survive the arsenic trioxide treatment by activation of ATM-mediated pathway. 2013 Apr 1 1
26 24004656 Importance of ERK activation in As2O3-induced differentiation and promyelocytic leukemia nuclear bodies formation in neuroblastoma cells. 2013 Nov 1
27 24211095 Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway. 2013 Dec 4
28 21308489 Arsenic trioxide induces apoptosis of p53 null osteosarcoma MG63 cells through the inhibition of catalase. 2012 Jun 3
29 21454520 Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. 2011 May 20 2
30 21792014 YY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide. 2011 Aug 1
31 20377131 Arsenic trioxide and promyelocytic leukemia protein-adenovirus synergistically inhibit in vitro and in vivo growth of a hepatoma cell line. 2010 1
32 20953137 Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2. 2010 Dec 1 4
33 19444595 Modulation of p53, c-fos, RARE, cyclin A, and cyclin D1 expression in human leukemia (HL-60) cells exposed to arsenic trioxide. 2009 Nov 1
34 19457607 Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation. 2009 Nov 1 2
35 19587434 [Effect of arsenic trioxide combined with adriamycin on the proliferation and apoptosis of human lymphoma cells]. 2009 Jun 1
36 17530438 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. 2008 Sep 1
37 18482988 Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase. 2008 Jul 4 8
38 18583568 Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. 2008 Sep 15 3
39 18668508 Requirement of a functional spindle checkpoint for arsenite-induced apoptosis. 2008 Oct 15 2
40 17332940 Arsenic trioxide induces p53-dependent apoptotic signals in myeloma cells with SiRNA-silenced p53: MAP kinase pathway is preferentially activated in cells expressing inactivated p53. 2007 Apr 3
41 17487067 Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin. 2007 1
42 18167198 Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells. 2007 Dec 20 9
43 16283431 Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. 2006 Jan 1
44 16467208 MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis. 2006 Jun 1 1
45 16646077 Clinically tolerable concentrations of arsenic trioxide induce p53-independent cell death and repress NF-kappa B activation in Ewing sarcoma cells. 2006 Oct 1 1
46 16891316 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. 2006 Sep 29 2
47 16950207 Synergistic induction of apoptosis by sulindac and arsenic trioxide in human lung cancer A549 cells via reactive oxygen species-dependent down-regulation of survivin. 2006 Nov 15 3
48 17064470 [Study of effects of HBV X gene and As2O3 on expression and activity of p53 in HepG2 cells with shRNA]. 2006 Oct 1
49 15904916 Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells. 2005 May 23 1
50 14726646 Arsenic trioxide and paclitaxel induce apoptosis by different mechanisms. 2004 Mar 1