Title : ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.

Pub. Date : 2006 Sep 29

PMID : 16891316






2 Functional Relationships(s)
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1 Based on this, we propose that a pathway composed of ATR, PML, Chk2, and p53 plays a role in ATO-mediated apoptosis, a notion that is consistent with the observation that Chk2 is genetically intact and mutations in the p53 gene are extremely rare in APL. Arsenic Trioxide tumor protein p53 Homo sapiens
2 Based on this, we propose that a pathway composed of ATR, PML, Chk2, and p53 plays a role in ATO-mediated apoptosis, a notion that is consistent with the observation that Chk2 is genetically intact and mutations in the p53 gene are extremely rare in APL. Arsenic Trioxide tumor protein p53 Homo sapiens