Title : Arsenic trioxide-mediated growth inhibition of myeloma cells is associated with an extrinsic or intrinsic signaling pathway through activation of TRAIL or TRAIL receptor 2.

Pub. Date : 2010 Dec 1

PMID : 20953137






4 Functional Relationships(s)
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1 In this study, the molecular mechanisms of ATO-induced myeloma apoptosis were explored on four myeloma cell lines of wild type or mutant p53 status and also on six primary myeloma cells. Arsenic Trioxide tumor protein p53 Homo sapiens
2 ATO treatment increased mRNA levels of interferon regulatory factor-1 and TRAIL, as well as protein levels of caspase 8 and cleaved caspase 3, indicating the involvement of the extrinsic apoptotic pathway in the mutated p53 myeloma cells. Arsenic Trioxide tumor protein p53 Homo sapiens
3 ATO also activated caspases 3 and 9, indicating involvement of the intrinsic apoptotic pathway in the wild type p53 myeloma cells. Arsenic Trioxide tumor protein p53 Homo sapiens
4 Together, our data suggest that ATO induces apoptosis in MM through either extrinsic or intrinsic signaling pathway, depending on the p53 genetic background. Arsenic Trioxide tumor protein p53 Homo sapiens