Pub. Date : 2010 Dec 1
PMID : 20953137
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In this study, the molecular mechanisms of ATO-induced myeloma apoptosis were explored on four myeloma cell lines of wild type or mutant p53 status and also on six primary myeloma cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
2 | ATO treatment increased mRNA levels of interferon regulatory factor-1 and TRAIL, as well as protein levels of caspase 8 and cleaved caspase 3, indicating the involvement of the extrinsic apoptotic pathway in the mutated p53 myeloma cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
3 | ATO also activated caspases 3 and 9, indicating involvement of the intrinsic apoptotic pathway in the wild type p53 myeloma cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
4 | Together, our data suggest that ATO induces apoptosis in MM through either extrinsic or intrinsic signaling pathway, depending on the p53 genetic background. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |