Title : Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression.

Pub. Date : 2011 May 20

PMID : 21454520






2 Functional Relationships(s)
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1 In this study, we found that wild type p53 is induced by arsenic trioxide in tumor cells, consistent with published studies. Arsenic Trioxide tumor protein p53 Homo sapiens
2 We also found that arsenic trioxide decreases the stability of mutant p53 protein through a proteasomal pathway, and blockage of mutant p53 nuclear export can alleviate the arsenic-induced mutant p53 degradation. Arsenic Trioxide tumor protein p53 Homo sapiens