Pub. Date : 2007 Dec 20
PMID : 18167198
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured HepG2 cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 2 | In recent years, effects of arsenic trioxide (As2O3) on the expression of p53 protein have been widely studied, while little is known about the activity of p53 protein. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 3 | In recent years, effects of arsenic trioxide (As2O3) on the expression of p53 protein have been widely studied, while little is known about the activity of p53 protein. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 4 | This study was undertaken to delineate the effect of HBV X gene and As2O3 on p53 protein expression (level and activity) in HepG2 cells by small hairpin RNA (shRNA)-mediated RNA interference (RNAi) technique. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 5 | The effect of As2O3 on p53 protein expression and activity was re-observed. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 6 | RESULTS: Total p53 protein level was up-regulated and its relative activity ratio was enhanced by As2O3 in HepG2 and HepG2-X cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 7 | The total p53 protein level induced by As2O3 was up-regulated by HBV X gene expression, while its relative activity was significantly suppressed. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 8 | CONCLUSIONS: As2O3 up-regulates p53 protein expression and enhance its activity. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 9 | HBV X up-regulates As2O3 induced-p53 protein expression while suppresses its activity. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |