Pub. Date : 2014 May 31
PMID : 24884809
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Mutation detection of p53 gene in arsenic trioxide resistant HCC cell lines was performed. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 2 | RESULTS: The acquisition of p53 mutation contributed to arsenic trioxide resistance and enhanced metastatic potential of HCC cells. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 3 | Mutant p53 (Mutp53) silence could re-sensitize HCC resistant cells to arsenic trioxide and inhibit the metastatic activities, while mutp53 overexpression showed the opposite effects. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSIONS: Acquisitions of p53 mutations contributed to the resistance of HCC to arsenic trioxide. | Arsenic Trioxide | tumor protein p53 | Homo sapiens |