Alanine

tumor protein p53 ; Homo sapiens







67 Article(s)
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1 32098913 β-Actin facilitates etoposide-induced p53 nuclear import. 2020 2
2 31592145 5-aminolaevulinic acid-based photodynamic therapy inhibits ultraviolet B-induced skin photodamage. 2019 1
3 28043143 Effects of ALA-PDT on HPV16-immortalized cervical epithelial cell. 2017 1
4 27777309 Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. 2016 Dec 9 1
5 25244701 Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins. 2014 Dec 1
6 22862424 The p53-dependent expression of frataxin controls 5-aminolevulinic acid-induced accumulation of protoporphyrin IX and photo-damage in cancerous cells. 2013 Jan-Feb 1
7 23388716 The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication. 2013 Apr 1
8 23667851 A case of late-onset Li-Fraumeni-like syndrome with unilateral breast cancer. 2013 May 1
9 23897481 Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. 2013 Aug 1
10 21737649 Phosphorylation of p53 modifies sensitivity to ionizing radiation. 2011 Jun 1
11 20847049 A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53. 2010 Nov 26 1
12 21103216 Proline residues link the active site to transmembrane domain movements in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3). 2010 Sep 2
13 19196987 Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. 2009 Feb 24 5
14 19331830 Residues in the alternative reading frame tumor suppressor that influence its stability and p53-independent activities. 2009 Apr 15 1
15 19766654 Identification of a function-specific mutation of clathrin heavy chain (CHC) required for p53 transactivation. 2009 Dec 4 2
16 19816404 ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. 2009 Dec 16 1
17 17467838 Functional determinants of NS2B for activation of Japanese encephalitis virus NS3 protease. 2007 Jul 1
18 16291740 Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 2006 Jan 20 2
19 16457841 Kinetic computational alanine scanning: application to p53 oligomerization. 2006 Mar 31 1
20 16940182 DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. 2006 Nov 1
21 15879716 Effects of Ser2 and Tyr6 mutants of BAF53 on cell growth and p53-dependent transcription. 2005 Apr 30 1
22 15946545 [Nuclear import of p53 in relation to MDM2-mediated degradation and ubiquitination]. 2005 Feb 1
23 14701864 ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. 2004 Mar 12 1
24 15116093 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. 2004 Apr 29 1
25 15364927 Negative regulation of p53 functions by Daxx and the involvement of MDM2. 2004 Nov 26 2
26 15381086 Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation. 2004 Oct 22 3
27 15464845 The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism. 2004 Oct 25 1
28 12524418 A novel case with germline p53 gene mutation having concurrent multiple primary colon tumours. 2003 Feb 1
29 12670900 Fas-mediated apoptosis is dependent on wild-type p53 status in human cancer cells expressing a temperature-sensitive p53 mutant alanine-143. 2003 Apr 1 1
30 12706118 Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression. 2003 May 1 1
31 11805282 Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis. 2002 Feb 5 1
32 11854596 Atypical pleomorphic extraosseous ewing tumor/peripheral primitive neuroectodermal tumor with unusual phenotypic/genotypic profile. 2002 Mar 1
33 11925449 The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. 2002 Aug 9 2
34 11960383 C-terminus of p53 is required for G(2) arrest. 2002 Mar 27 2
35 11971195 Multiple lysine mutations in the C-terminus of p53 make it resistant to degradation mediated by MDM2 but not by human papillomavirus E6 and induce growth inhibition in MDM2-overexpressing cells. 2002 Apr 11 1
36 12167711 Hypophosphorylation of Mdm2 augments p53 stability. 2002 Sep 1
37 11078726 Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. 2001 Feb 16 2
38 11358908 Concurrent occurrence of gastric adenocarcinoma and duodenal neuroendocrine cell carcinoma: a composite tumour or collision tumours ? 2001 Jun 1
39 11483158 Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity. 2001 2
40 11521201 The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis. 2001 Aug 9 2
41 11713288 Identification of p53 sequence elements that are required for MDM2-mediated nuclear export. 2001 Dec 3
42 10660538 Human and mouse Fas (APO-1/CD95) death receptor genes each contain a p53-responsive element that is activated by p53 mutants unable to induce apoptosis. 2000 Feb 11 2
43 10884347 The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. 2000 Jul 14 1
44 11016934 Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins. 2000 Dec 29 1
45 11033015 Critical residues of epitopes recognized by several anti-p53 monoclonal antibodies correspond to key residues of p53 involved in interactions with the mdm2 protein. 2000 Oct 20 2
46 11080808 Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax. 2000 Nov 1 2
47 10484981 Hereditary TP53 codon 292 and somatic P16INK4A codon 94 mutations in a Li-Fraumeni syndrome family. 1999 Sep 1
48 9582268 Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain. 1998 May 15 1
49 9620557 The H19 TATA-less promoter is efficiently repressed by wild-type tumor suppressor gene product p53. 1998 May 7 1
50 9213246 Wild-type p53 gene-induced morphological changes and growth suppression in hepatoma cells. 1997 Jun 2