Title : ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.

Pub. Date : 2004 Mar 12

PMID : 14701864






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the Glu(373)-Ala(374) interglobular domain bond of aggrecan. Alanine tumor protein p53 Homo sapiens