Title : Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21(WAF1) expression.

Pub. Date : 2003 May 1

PMID : 12706118






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We have found up-regulated levels of the cyclin-dependent kinase 2 (cdk2) protein in HDF expressing 143(ala) mutant p53 as compared to senescent controls, together with an increase in p21-free cdk2 which, in conjunction with cyclin E, is able to form an active kinase which can phosphorylate the retinoblastoma protein. Alanine tumor protein p53 Homo sapiens