Title : Negative regulation of p53 functions by Daxx and the involvement of MDM2.

Pub. Date : 2004 Nov 26

PMID : 15364927






2 Functional Relationships(s)
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1 Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction. Alanine tumor protein p53 Homo sapiens
2 Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys to Arg mutations preserved, but Lys to Ala or Ser to Glu mutations abolished Daxx-p53 interaction. Alanine tumor protein p53 Homo sapiens