Title : Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins.

Pub. Date : 2000 Dec 29

PMID : 11016934






1 Functional Relationships(s)
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1 Using a combination of alanine scanning, polymer blot analysis, and photoaffinity labeling, we have identified poly(ADP-ribose)-binding sites in the following proteins: p53, p21(CIP1/WAF1), xeroderma pigmentosum group A complementing protein, MSH6, DNA ligase III, XRCC1, DNA polymerase epsilon, DNA-PK(CS), Ku70, NF-kappaB, inducible nitric-oxide synthase, caspase-activated DNase, and telomerase. Alanine tumor protein p53 Homo sapiens