Title : Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins.

Pub. Date : 2014 Dec

PMID : 25244701






1 Functional Relationships(s)
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1 Using the intrinsically disordered N-terminal region of the p53 protein as an experimental model, a set of proline (PRO) and alanine (ALA) to glycine (GLY) substitution variants were designed to modulate backbone conformational propensities without introducing non-native intramolecular interactions. Alanine tumor protein p53 Homo sapiens