Tacrolimus

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







240 Article(s)
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101 25894154 Polymorphism of the CYP3A5 gene and its effect on tacrolimus blood level. 2015 Apr 2
102 25916520 Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment. 2015 4
103 25968921 Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report. 2015 2
104 26039043 Effects of the CYP3A4*1B Genetic Polymorphism on the Pharmacokinetics of Tacrolimus in Adult Renal Transplant Recipients: A Meta-Analysis. 2015 10
105 26067485 Multigene predictors of tacrolimus exposure in kidney transplant recipients. 2015 Jul 1
106 26114223 Progressive decline in tacrolimus clearance after renal transplantation is partially explained by decreasing CYP3A4 activity and increasing haematocrit. 2015 Sep 3
107 26184414 Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. 2015 Sep 1
108 26227094 The genetic polymorphisms of POR*28 and CYP3A5*3 significantly influence the pharmacokinetics of tacrolimus in Chinese renal transplant recipients. 2015 Sep 1
109 26228923 Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients. 2015 2
110 26271661 Personalizing initial calcineurin inhibitor dosing by adjusting to donor CYP3A-status in liver transplant patients. 2015 Dec 2
111 26334901 Donor PPARα Gene Polymorphisms Influence the Susceptibility to Glucose and Lipid Disorders in Liver Transplant Recipients: A Strobe-Compliant Observational Study. 2015 Sep 4
112 26615671 Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post-transplant phase. 2015 Dec 2
113 26770526 Relationships of related genetic polymorphisms and individualized medication of tacrolimus in patients with renal transplantation. 2015 2
114 24033383 Impact of CYP3A5 genetic polymorphisms on the pharmacokinetics and short-term remission in patients with ulcerative colitis treated with tacrolimus. 2014 Jan 1
115 24061445 Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. 2014 Feb 1
116 24126681 Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. 2014 Apr 2
117 24249597 The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. 2014 Feb 2
118 24369269 Successful telaprevir treatment in combination of cyclosporine against recurrence of hepatitis C in the Japanese liver transplant patients. 2014 1
119 24444408 CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-adjusted trough concentrations in kidney transplant recipients. 2014 Feb 1
120 24462213 Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp. 2014 Apr 15 4
121 24522145 Effect of CYP3A4*22, CYP3A5*3, and CYP3A Combined Genotypes on Cyclosporine, Everolimus, and Tacrolimus Pharmacokinetics in Renal Transplantation. 2014 Feb 12 1
122 24526611 Determination of the most influential sources of variability in tacrolimus trough blood concentrations in adult liver transplant recipients: a bottom-up approach. 2014 May 1
123 24656020 Effects of elevated tacrolimus trough levels in association with infectious enteritis on graft function in renal transplant recipients. 2014 1
124 24658827 The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. 2014 Jun 1
125 24739669 CYP3A5*3 and POR*28 genetic variants influence the required dose of tacrolimus in heart transplant recipients. 2014 Dec 1
126 25125128 Colchicine levels in chronic kidney diseases and kidney transplant recipients using tacrolimus. 2014 Oct 1
127 25141896 Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. 2014 Jun 1
128 25322286 Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients. 2014 Dec 2
129 25561870 Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin. 2014 Dec 1
130 28346678 CORRIGENDUM: Identification and Characterization of a Defective CYP3A4 Genotype in a Kidney Transplant Patient With Severely Diminished Tacrolimus Clearance. 2014 Nov 1
131 23107770 Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients. 2013 Jan 10 4
132 23163400 The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations. 2013 Jun 1
133 23175667 Increased hospital stay and allograft dysfunction in renal transplant recipients with Cyp2c19 AA variant in SNP rs4244285. 2013 Feb 2
134 23252948 CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy. 2013 Jan 4
135 23278282 Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. 2013 Jul 3
136 23364483 CYP3A and ABCB1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tacrolimus and its metabolites (M-I and M-III). 2013 Mar 27 1
137 23459029 Effects of CYP3A4 and CYP3A5 polymorphisms on tacrolimus pharmacokinetics in Chinese adult renal transplant recipients: a population pharmacokinetic analysis. 2013 May 7
138 23481136 Cytochrome P450 3A4FNx011B as pharmacogenomic predictor of tacrolimus pharmacokinetics and clinical outcome in the liver transplant recipients. 2013 Mar-Apr 2
139 23557867 CYP3A4/5 polymorphisms affect the blood level of cyclosporine and tacrolimus in Chinese renal transplant recipients. 2013 Jun 4
140 23574377 Severe acute nephrotoxicity in a kidney transplant patient despite low tacrolimus levels: a possible interaction between donor and recipient genetic polymorphisms. 2013 Aug 1
141 23617933 Biological interactions of CYP2C19 genotypes with CYP3A4*18, CYP3A5*3, and MDR1-3435 in living donor liver transplantation recipients. 2013 Apr 23 1
142 23778326 A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-transplanted patients. 2013 Aug 2
143 23837477 CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. 2013 Jul 8
144 23947183 [Personalized medicine in transplantation therapy]. 2013 May 1
145 24024898 Impact of CYP3A5 genotype on tacrolimus versus midazolam clearance in renal transplant recipients: new insights in CYP3A5-mediated drug metabolism. 2013 Sep 1
146 24052064 Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines. 2013 Oct 3
147 24189425 Influence of cytochrome P450 (CYP) 3A4*1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. 2013 2
148 22108237 The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. 2012 Jan 1
149 22205779 Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. 2012 Apr 1
150 22310591 Impact of cytochrome P450 3A and ATP-binding cassette subfamily B member 1 polymorphisms on tacrolimus dose-adjusted trough concentrations among Korean renal transplant recipients. 2012 Jan 4