Tacrolimus

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







240 Article(s)
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51 29256966 Influence of donor liver CYP3A4*20 loss-of-function genotype on tacrolimus pharmacokinetics in transplanted patients. 2018 Feb 4
52 29469606 Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype. 2018 Mar 1
53 29546446 CYP3A4 and GCK genetic polymorphisms are the risk factors of tacrolimus-induced new-onset diabetes after transplantation in renal transplant recipients. 2018 Jun 3
54 29547545 Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients. 2018 Mar 16 2
55 29615122 Effect of CYP3 A4, CYP3 A5 and ABCB1 gene polymorphisms on the clinical efficacy of tacrolimus in the treatment of nephrotic syndrome. 2018 Apr 3 1
56 29629825 CYP3A pharmacogenetic association with tacrolimus pharmacokinetics differs based on route of drug administration. 2018 Apr 3
57 29733390 Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients. 2018 Sep 1 2
58 29801578 The Pharmacogenetics of Immune-Modulating Therapy. 2018 1
59 29804290 Tacrolimus Elimination in Four Patients With a CYP3A5*3/*3 CYP3A4*22/*22 Genotype Combination. 2018 Jul 4
60 29920787 Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. 2018 Aug 3
61 30040022 Tacrolimus population pharmacokinetic models according to CYP3A5/CYP3A4/POR genotypes in Chinese Han renal transplant patients. 2018 Aug 1 1
62 30156148 Individualized Tacrolimus Therapy for Pediatric Nephrotic Syndrome: Considerations for Ontogeny and Pharmacogenetics of CYP3A. 2018 2
63 30166405 Relationship between In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Systemic Tacrolimus Metabolite/Parent Drug Ratio in Renal Transplant Recipients and Healthy Volunteers. 2018 Nov 2
64 30251601 Influence of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics/Pharmacodynamics of Tacrolimus in Pediatric Patients. 2018 2
65 27378609 Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype. 2017 Dec 1
66 27822915 Analysis of the variable factors influencing tacrolimus blood concentration during the switch from continuous intravenous infusion to oral administration after allogeneic hematopoietic stem cell transplantation. 2017 Mar 1
67 27890698 Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice. 2017 Jan 15 2
68 28008657 Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance. 2017 Jun 1
69 28044353 Donor CYP3A5 genotype influences tacrolimus disposition on the first day after paediatric liver transplantation. 2017 Jun 1
70 28050888 A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach. 2017 Aug 3
71 28146606 The CYP3A biomarker 4β-hydroxycholesterol does not improve tacrolimus dose predictions early after kidney transplantation. 2017 Jul 3
72 28168728 Response to: 'Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. 2017 Jun 1
73 28219593 Betel Nut Chewing Is Associated With Reduced Tacrolimus Concentration in Taiwanese Liver Transplant Recipients. 2017 Mar 1
74 28229376 The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients. 2017 Jun 3
75 28324194 Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3. 2017 Jun 1
76 28374426 Response to: 'Response to: Bodyweight-adjustments introduce significant correlations between CYP3A metrics and tacrolimus clearance'. 2017 Jun 1
77 28603840 Pretransplant 4β-hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. 2017 Nov 1
78 28621555 SLC28A3 rs7853758 as a new biomarker of tacrolimus elimination and new-onset hypertension in Chinese liver transplantation patients. 2017 Aug 2
79 28642710 Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation. 2017 3
80 28655393 The role of single nucleotide polymorphisms of CYP3A and ABCB1 on tacrolimus predose concentration in kidney transplant recipients. 2017 Supplement 1 2
81 28704257 The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation. 2017 Sep 1
82 28722255 Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. 2017 Oct 1
83 28777242 Analysis of common polymorphisms within NR1I2 and NR1I3 genes and tacrolimus dose-adjusted concentration in stable kidney transplant recipients. 2017 Oct 1
84 28945481 Long-Term Influence of CYP3A5, CYP3A4, ABCB1, and NR1I2 Polymorphisms on Tacrolimus Concentration in Chinese Renal Transplant Recipients. 2017 Nov 3
85 29050276 A new donors' CYP3A5 and recipients' CYP3A4 cluster predicting tacrolimus disposition, and new-onset hypertension in Chinese liver transplant patients. 2017 Sep 19 1
86 26239045 Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole. 2016 Apr 1
87 26433738 Factors associated with 1,25-dihydroxyvitamin D3 concentrations in liver transplant recipients: a prospective observational longitudinal study. 2016 Apr 2
88 26521259 Population pharmacokinetics and pharmacogenetics of once daily tacrolimus formulation in stable liver transplant recipients. 2016 Feb 1
89 26651976 Influence of CYP3A5 polymorphism on the pharmacokinetics of psychiatric drugs. 2016 1
90 26924289 Prediction of tacrolimus metabolism and dosage requirements based on CYP3A4 phenotype and CYP3A5(*)3 genotype in Chinese renal transplant recipients. 2016 Apr 2
91 27225724 Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. 2016 May 5
92 27310200 Risk Assessment of Drug-Drug Interactions of Calcineurin Inhibitors Affecting Sirolimus Pharmacokinetics in Renal Transplant Patients. 2016 Oct 1
93 27314545 CYP3A pharmacogenetics and tacrolimus disposition in adult heart transplant recipients. 2016 Sep 3
94 27399255 Drug interaction between dabrafenib and immunosuppressive drugs: about one case. 2016 Oct 1
95 25271728 Which Genetic Determinants Should be Considered for Tacrolimus Dose Optimization in Kidney Transplantation? A Combined Analysis of Genes Affecting the CYP3A Locus. 2015 Jun 1
96 25287072 The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients. 2015 Apr 2
97 25588704 Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations. 2015 Mar 2
98 25600613 In vitro-in vivo extrapolations to evaluate the effect of concomitant drugs on tacrolimus (FK506) exposure. 2015 Jul 3
99 25877445 Reversible, time-dependent inhibition of CYP3A-mediated metabolism of midazolam and tacrolimus by telaprevir in human liver microsomes. 2015 2
100 25881619 Lack of a significant pharmacokinetic interaction between maraviroc and tacrolimus in allogeneic HSCT recipients. 2015 Jul 1