Title : Effect of Tacrolimus on the pharmacokinetics of bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) and the potential roles of CYP3A and P-gp.

Pub. Date : 2014 Apr 15

PMID : 24462213






4 Functional Relationships(s)
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1 Metabolism study in the human recombinant CYP 3A showed that these lignans had higher affinity to CYP3A than that of FK506, and thus had a stronger CYP3A-mediated metabolism. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Metabolism study in the human recombinant CYP 3A showed that these lignans had higher affinity to CYP3A than that of FK506, and thus had a stronger CYP3A-mediated metabolism. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 It was concluded that the blood concentrations of these lignans were decreased and their CYP3A-mediated metabolisms were increased in the presence of FK506 since these lignans had higher affinity to CYP3A. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 It was concluded that the blood concentrations of these lignans were decreased and their CYP3A-mediated metabolisms were increased in the presence of FK506 since these lignans had higher affinity to CYP3A. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens