Tacrolimus

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







240 Article(s)
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151 22369694 Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation. 2012 Apr 1
152 22476221 Hepatitis C virus treatment and liver transplantation in the era of new antiviral therapies. 2012 Jun 1
153 22491658 Risk of tacrolimus toxicity in CYP3A5 nonexpressors treated with intravenous nicardipine after kidney transplantation. 2012 Apr 27 1
154 22576324 Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers. 2012 Nov 1
155 22871995 In vivo CYP3A4 activity, CYP3A5 genotype, and hematocrit predict tacrolimus dose requirements and clearance in renal transplant patients. 2012 Sep 6
156 22993851 [Effect of CYP3A4*18B, CYP3A5*3 gene polymorphism on dosage and concentration of tacrolimus in renal transplant patients]. 2012 Jul 2
157 23580932 Formulation strategies for drug delivery of tacrolimus: An overview. 2012 Oct 1
158 21635144 Impact of the CYP3A4*1G polymorphism and its combination with CYP3A5 genotypes on tacrolimus pharmacokinetics in renal transplant patients. 2011 Jul 9
159 21753749 In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients. 2011 Sep 3
160 21844990 Tacrolimus and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors: An interaction study in CYP3A5 non-expressors, renal transplant recipients. 2011 Jul 1
161 21902502 Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients. 2011 Oct 2
162 21903774 A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. 2011 Nov 1
163 21916909 Association of ABCB1, CYP3A4*18B and CYP3A5*3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects: a population pharmacokinetic analysis. 2011 Oct 1
164 21980965 Successful tacrolimus treatment following renal transplant in a HIV-infected patient with raltegravir previously treated with a protease inhibitor based regimen. 2011 1
165 22016125 [Drug interactions and immunosuppression in organ transplant recipients]. 2011 Oct 18 1
166 20091056 Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics. 2010 May 1
167 20097278 Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). 2010 Apr 15 2
168 20305320 Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient. 2010 Jan-Mar 1
169 20718999 Probable tacrolimus toxicity from tibolone co-administration in a woman: a case report. 2010 Aug 19 1
170 20832577 Micafungin does not influence the concentration of tacrolimus in patients after allogeneic hematopoietic stem cell transplantation. 2010 Sep 1
171 20876828 Ranolazine-tacrolimus interaction. 2010 Nov 1
172 21047202 Using genetic and clinical factors to predict tacrolimus dose in renal transplant recipients. 2010 Oct 2
173 21104927 Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations. 2010 Nov 2
174 19183931 [Drug-drug interactions in urology]. 2009 Mar 1
175 19289993 The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients. 2009 Jan-Mar 1
176 19376366 Genetic polymorphisms in CYP3A5 and MDR1 genes and their correlations with plasma levels of tacrolimus and cyclosporine in renal transplant recipients. 2009 Apr 1
177 19384171 Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea. 2009 Apr 27 6
178 19667964 Pharmacogenetics of calcineurin inhibitors in renal transplantation. 2009 Aug 15 1
179 19709321 Effect of coadministered HIV-protease inhibitors on tacrolimus and sirolimus blood concentrations in a kidney transplant recipient. 2009 Aug 2
180 19728747 Immunotherapy in elderly transplant recipients: a guide to clinically significant drug interactions. 2009 1
181 19813492 Tacrolimus: review of pharmacokinetics, pharmacodynamics, and pharmacogenetics to facilitate practitioners' understanding and offer strategies for educating patients and promoting adherence. 2009 Sep 3
182 18493655 Bifunctional molecules evade cytochrome P(450) metabolism by forming protective complexes with FK506-binding protein. 2008 Jun 1
183 18556719 Effect of aprepitant on intravenous tacrolimus disposition in reduced intensity hematopoietic stem cell transplantation. 2008 Sep 1
184 18704002 Effects of CYP3A5 and MDR1 single nucleotide polymorphisms on drug interactions between tacrolimus and fluconazole in renal allograft recipients. 2008 Oct 1
185 18721002 Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers. 2008 1
186 19005401 Haplotypic structure of ABCB1/MDR1 gene modifies the risk of the acute allograft rejection in renal transplant recipients. 2008 Nov 15 1
187 17202802 Effect of cyclosporine and tacrolimus on cytochrome p450 activities in human liver microsomes. 2007 Jan 1
188 17374625 Does metronidazole interact with CYP3A substrates by inhibiting their metabolism through this metabolic pathway? Or should other mechanisms be considered? 2007 Apr 1
189 17495880 CYP3A5 and CYP3A4 but not MDR1 single-nucleotide polymorphisms determine long-term tacrolimus disposition and drug-related nephrotoxicity in renal recipients. 2007 Dec 7
190 17889118 Pharmacogenetics of tacrolimus and sirolimus in renal transplant patients: from retrospective analyses to prospective studies. 2007 Sep 2
191 17979656 Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs. 2007 Oct 1
192 18159131 Distinct effects of omeprazole and rabeprazole on the tacrolimus blood concentration in a kidney transplant recipient. 2007 Dec 1
193 16421475 Influence of CYP3A5 gene polymorphisms of donor rather than recipient to tacrolimus individual dose requirement in liver transplantation. 2006 Jan 15 1
194 16424824 Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients. 2006 Feb 1
195 16753004 Influence of different allelic variants of the CYP3A and ABCB1 genes on the tacrolimus pharmacokinetic profile of Chinese renal transplant recipients. 2006 Jun 3
196 16759707 An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. 2006 Oct 1
197 16906020 Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients. 2006 Sep 4
198 16911928 Genetic factors for individual administration of immunosuppressants in organ transplantation. 2006 Aug 1
199 15698457 Impact of gastric acid suppressants on cytochrome P450 3A4 and P-glycoprotein: consequences for FK506 assimilation. 2005 Mar 3
200 15919446 Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients. 2005 May 1