Title : Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach.

Pub. Date : 2014 Jun

PMID : 25141896






1 Functional Relationships(s)
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1 Time post-transplantation, recipient age, donor CYP3A5 and CYP3A4 genotypes and fluconazole administration significantly influenced tacrolimus apparent clearance while bodyweight influenced volume of distribution. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens