Title : Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease.

Pub. Date : 2015 Sep

PMID : 26184414






1 Functional Relationships(s)
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1 CONCLUSIONS: In CYP3A5*3/*3 patients, because the metabolic pathway for tacrolimus occurs only through CYP3A4, the combination with ITCZ seems to lead to a higher risk of acute renal dysfunction. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens