Title : Interactive effects of CYP3A4, CYP3A5, MDR1 and NR1I2 polymorphisms on tracrolimus trough concentrations in early postrenal transplant recipients.

Pub. Date : 2015

PMID : 26228923






2 Functional Relationships(s)
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1 CYP3A4*1G, MDR1 1236-2677-3435 diplotype and NR1I2 -25385C > T explained 21.4% of variability of tacrolimus C0D7/D in CYP3A5 nonexpressers. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Genotyping of CYP3A4/MDR1/NR1I2 polymorphisms may be helpful for better guiding tacrolimus dosing in CYP3A5 nonexpressers. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens