Gefitinib

AKT serine/threonine kinase 1 ; Homo sapiens







219 Article(s)
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51 26870244 Integrin β1-mediated acquired gefitinib resistance in non-small cell lung cancer cells occurs via the phosphoinositide 3-kinase-dependent pathway. 2016 Jan 4
52 27125283 Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer. 2016 Apr 29 1
53 27283902 PA-MSHA in combination with EGFR tyrosine kinase inhibitor: A new strategy to overcome the drug resistance of non-small cell lung cancer cells. 2016 Aug 2 1
54 27346398 [Effect of autophagy inhibitor combined with EGFR inhibitor on triple-negative breast cancer MDA-MB-468 and MDA-MB-231 cells]. 2016 Jun 23 2
55 27347100 Gefitinib induces lung cancer cell autophagy and apoptosis via blockade of the PI3K/AKT/mTOR pathway. 2016 Jul 3
56 27494877 FOXM1 confers resistance to gefitinib in lung adenocarcinoma via a MET/AKT-dependent positive feedback loop. 2016 Sep 13 1
57 27629794 Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. 2016 Nov 1
58 27690301 MiR-128 reverses the gefitinib resistance of the lung cancer stem cells by inhibiting the c-met/PI3K/AKT pathway. 2016 Nov 8 2
59 27698894 AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells. 2016 2
60 27716616 Ran GTPase promotes cancer progression via Met recepto-rmediated downstream signaling. 2016 Nov 15 1
61 27877053 Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma. 2016 1
62 27989877 Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression. 2016 Dec 24 3
63 28101246 Detection of microRNA-200b may predict the inhibitory effect of gefitinib on non-small cell lung cancer and its potential mechanism. 2016 Dec 1
64 25454348 Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer. 2015 Feb 1
65 25488183 Enoxaparin sensitizes human non-small-cell lung carcinomas to gefitinib by inhibiting DOCK1 expression, vimentin phosphorylation, and Akt activation. 2015 1
66 25588160 Combination of SF1126 and gefitinib induces apoptosis of triple-negative breast cancer cells through the PI3K/AKT-mTOR pathway. 2015 Apr 4
67 25653196 EGF‑stimulated AKT activation is mediated by EGFR recycling via an early endocytic pathway in a gefitinib‑resistant human lung cancer cell line. 2015 Apr 1
68 25662161 Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells. 2015 May 15 6
69 25674002 NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation. 2015 2
70 26063323 Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway. 2015 Aug 1
71 26176330 The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors. 2015 1
72 26203858 Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT. 2015 Jul 23 3
73 26517520 244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells. 2015 Dec 29 1
74 26622906 Synergistic interaction between MEK inhibitor and gefitinib in EGFR-TKI-resistant human lung cancer cells. 2015 Oct 2
75 24268810 Fulvestrant increases gefitinib sensitivity in non-small cell lung cancer cells by upregulating let-7c expression. 2014 Apr 1
76 24374738 The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism. 2014 Jun 1 3
77 24486412 Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells. 2014 May 1
78 24631288 Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR. 2014 May 1 1
79 24840891 Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. 2014 Aug 1
80 24884778 Enhancement of gefitinib-induced growth inhibition by Marsdenia tenacissima extract in non-small cell lung cancer cells expressing wild or mutant EGFR. 2014 May 22 2
81 24957682 AKT inhibition synergistically enhances growth-inhibitory effects of gefitinib and increases apoptosis in non-small cell lung cancer cell lines. 2014 Aug 1
82 25058005 Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer. 2014 2
83 25275600 Gefitinib targets ZAP-70-expressing chronic lymphocytic leukemia cells and inhibits B-cell receptor signaling. 2014 Oct 2 1
84 25623760 [Effect of recombinant human p53 adenovirus (Ad-p53) combined with EGFR inhibitor gefitinib on the sensitivity of breast cancer MDA-MB-468 cells]. 2014 Dec 2
85 23102728 MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 2013 Feb 1
86 23111983 Apoptosis induced by benzyl isothiocyanate in gefitinib-resistant lung cancer cells is associated with Akt/MAPK pathways and generation of reactive oxygen species. 2013 May 1
87 23200321 Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition. 2013 Jun 2
88 23270470 Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines. 2013 Mar 1
89 23344263 Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. 2013 Feb 15 1
90 23525575 Combined inhibition of the EGFR and mTOR pathways in EGFR wild-type non-small cell lung cancer cell lines with different genetic backgrounds. 2013 Jun 1
91 23601074 Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells. 2013 May 2
92 23714663 [Small molecule inhibitor SB203580 enhances the antitumor effect of gefitinib in PC-9 and A549 lung cancer cell lines]. 2013 Feb 1
93 23849826 Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity. 2013 Oct 1
94 23959460 Effects of pemetrexed, gefitinib, and their combination on human colorectal cancer cells. 2013 Oct 1
95 23962905 Crizotinib overcomes hepatocyte growth factor-mediated resistance to gefitinib in EGFR-mutant non-small-cell lung cancer cells. 2013 Nov 1
96 24071646 Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells. 2013 Sep 26 2
97 24146879 Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer. 2013 1
98 24280348 Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells. 2013 Dec 2
99 24325059 [Effect of bufalin combined gefitinib on lung cancer H1975 cells and its mechanisms research]. 2013 Aug 1
100 24337846 Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells. 2013 Dec 3