Title : Synergistic interaction between MEK inhibitor and gefitinib in EGFR-TKI-resistant human lung cancer cells.

Pub. Date : 2015 Oct

PMID : 26622906






2 Functional Relationships(s)
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1 Treatment of A549 cells with gefitinib alone reduced the expression level of the activated form of Akt, and the combination of the two drugs showed stronger inhibition of phosphorylated-Akt and phosphorylated-extracellular signal-regulated kinases. Gefitinib AKT serine/threonine kinase 1 Homo sapiens
2 Treatment of A549 cells with gefitinib alone reduced the expression level of the activated form of Akt, and the combination of the two drugs showed stronger inhibition of phosphorylated-Akt and phosphorylated-extracellular signal-regulated kinases. Gefitinib AKT serine/threonine kinase 1 Homo sapiens