Title : Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression.

Pub. Date : 2016 Dec 24

PMID : 27989877






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Chinese herbal medicine Fuzheng Kang-Ai decoction sensitized the effect of gefitinib on inhibition of human lung cancer cells through inactivating PI3-K/Akt -mediated suppressing MUC1 expression. Gefitinib AKT serine/threonine kinase 1 Homo sapiens
2 Mechanistically, we showed that the phosphorylation of Akt, protein expressions of p65 and MUC1 were suppressed by FZKA and even more responses were observed in the FZKA and gefitinib combining. Gefitinib AKT serine/threonine kinase 1 Homo sapiens
3 In line with the above, our results confirmed the synergistic effects of FZKA and gefitinib combination on tumor growth, the phosphorylation of Akt, and protein expression of p65 and MUC1 in vivo. Gefitinib AKT serine/threonine kinase 1 Homo sapiens