Pub. Date : 2014 Jun 1
PMID : 24374738
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The activation of AKT was associated with disease progression in tumors with wild-type EGFR from patients treated with gefitinib (phase II clinical trial IFCT0401). | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The PI3K/AKT pathway is thus a major pathway contributing to gefitinib resistance in lung tumors with KRAS mutation, through the regulation of the BAX/Ku70 interaction. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |