Title : Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells.

Pub. Date : 2014 May

PMID : 24486412






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Blocking the TGF-alpha/EGFR pathway by gefitinib, a specific EGFR inhibitor, reduced the activation of STAT (signal transducer and activator of transcription) 3, AKT and ERK (extracellular signal-regulated kinase), and synergized with sorafenib to inhibit proliferation and induce apoptosis of hypoxic HCC cells. Gefitinib AKT serine/threonine kinase 1 Homo sapiens