Pub. Date : 2015 Jul 23
PMID : 26203858
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reciprocal positive regulation between Cx26 and PI3K/Akt pathway confers acquired gefitinib resistance in NSCLC cells via GJIC-independent induction of EMT. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Cx26-mediated EMT and gefitinib resistance were significantly blocked by inhibition of PI3K/Akt pathway. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, the reciprocal positive regulation between Cx26 and PI3K/Akt signaling contributes to acquired gefitinib resistance in NSCLC cells by promoting EMT via a GJIC-independent manner. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |