Title : Detection of microRNA-200b may predict the inhibitory effect of gefitinib on non-small cell lung cancer and its potential mechanism.

Pub. Date : 2016 Dec

PMID : 28101246






1 Functional Relationships(s)
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1 Upregulation of microRNA-200b led to the elevated sensitivity of glioma cells to gefitinib, and this effect may be explained as microRNA-200b being able to inhibit the expression of IGF-1R, thereby reducing the activation of downstream phosphoinositide 3-kinase/AKT and mitogen-activated protein kinase signaling pathways. Gefitinib AKT serine/threonine kinase 1 Homo sapiens