Pub. Date : 2015 Apr
PMID : 25588160
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combination of SF1126 and gefitinib induces apoptosis of triple-negative breast cancer cells through the PI3K/AKT-mTOR pathway. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, phosphorylated AKT (p-AKT) and 70 kDa ribosomal protein S6-kinase (p-p70S6K) were also inhibited by the gefitinib and SF1126 combination, which may be responsible for the apoptosis. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Moreover, phosphorylated AKT (p-AKT) and 70 kDa ribosomal protein S6-kinase (p-p70S6K) were also inhibited by the gefitinib and SF1126 combination, which may be responsible for the apoptosis. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Gefitinib combined with SF1126 could induce cell apoptosis in TNBC cells and this effect was mediated through the EGFR-PI3K-AKT-mTOR-p70S6K pathway. | Gefitinib | AKT serine/threonine kinase 1 | Homo sapiens |