| 101 |
24341609 | Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor. | 2013 Dec 17 |
1 |
| 102 |
21544845 | Regulation of cigarette smoke-mediated mucin expression by hypoxia-inducible factor-1α via epidermal growth factor receptor-mediated signaling pathways. | 2012 Apr |
1 |
| 103 |
21959795 | Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation. | 2012 Jul |
1 |
| 104 |
22057914 | MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. | 2012 Jan |
1 |
| 105 |
22313686 | Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells. | 2012 Apr |
1 |
| 106 |
22315058 | Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway. | 2012 Mar 13 |
2 |
| 107 |
22317763 | Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer. | 2012 Mar 15 |
1 |
| 108 |
22414764 | Epidermal growth factor receptor and HER-3 restrict cell response to sorafenib in hepatocellular carcinoma cells. | 2012 Jul |
1 |
| 109 |
22502680 | MicroRNA-214 regulates the acquired resistance to gefitinib via the PTEN/AKT pathway in EGFR-mutant cell lines. | 2012 |
2 |
| 110 |
22780923 | [Effect of gefitinib on the migration of triple-negative breast cancer cell line MDA-MB-231 cells]. | 2012 Feb |
1 |
| 111 |
22922893 | Inhibition of the AKT/mTOR and erbB pathways by gefitinib, perifosine and analogs of gonadotropin-releasing hormone I and II to overcome tamoxifen resistance in breast cancer cells. | 2012 Nov |
1 |
| 112 |
22923287 | Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2. | 2012 Nov |
1 |
| 113 |
22941374 | Everolimus synergizes with gefitinib in non-small-cell lung cancer cell lines resistant to epidermal growth factor receptor tyrosine kinase inhibitors. | 2012 Nov |
1 |
| 114 |
21087080 | Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. | 2011 Feb |
1 |
| 115 |
21220474 | Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer. | 2011 Apr 15 |
2 |
| 116 |
21479670 | Phosphorylated insulin-like growth factor 1 receptor is implicated in resistance to the cytostatic effect of gefitinib in colorectal cancer cells. | 2011 Jun |
1 |
| 117 |
21487020 | Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. | 2011 Jun 10 |
1 |
| 118 |
21655094 | EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. | 2011 |
1 |
| 119 |
21660955 | Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. | 2011 Sep |
1 |
| 120 |
21741919 | DARPP-32 increases interactions between epidermal growth factor receptor and ERBB3 to promote tumor resistance to gefitinib. | 2011 Nov |
1 |
| 121 |
21878657 | Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. | 2011 Nov |
1 |
| 122 |
21961726 | Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells. | 2011 Oct 2 |
2 |
| 123 |
22016830 | N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells. | 2011 |
1 |
| 124 |
22037177 | Blocking the PI3K/AKT and MEK/ERK signaling pathways can overcome gefitinib-resistance in non-small cell lung cancer cell lines. | 2011 |
1 |
| 125 |
22111840 | Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines. | 2011 Nov 23 |
1 |
| 126 |
22977626 | Combined inhibition of insulin-like growth factor-1 receptor enhances the effects of gefitinib in a human non-small cell lung cancer resistant cell line. | 2011 Nov |
1 |
| 127 |
19756373 | Preclinical activity of gefitinib in non-keratinizing nasopharyngeal carcinoma cell lines and biomarkers of response. | 2010 Jun |
1 |
| 128 |
19760159 | Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. | 2010 Dec |
1 |
| 129 |
19921194 | Combined inhibition of IGFR enhances the effects of gefitinib in H1650: a lung cancer cell line with EGFR mutation and primary resistance to EGFR-TK inhibitors. | 2010 Jul |
1 |
| 130 |
19922467 | EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors. | 2010 Jan |
1 |
| 131 |
19946741 | Effects of the combined blockade of EGFR and ErbB-2 on signal transduction and regulation of cell cycle regulatory proteins in breast cancer cells. | 2010 Sep |
1 |
| 132 |
19956829 | A novel pharmacodynamic approach to assess and predict tumor response to the epidermal growth factor receptor inhibitor gefitinib in patients with esophageal cancer. | 2010 Jan |
1 |
| 133 |
20097187 | MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancer. | 2010 Mar 30 |
1 |
| 134 |
20159991 | Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib. | 2010 Mar |
3 |
| 135 |
20444542 | Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells. | 2010 Oct 28 |
2 |
| 136 |
20651347 | Antiproliferative effects of antiestrogens and inhibitors of growth factor receptor signaling on endometrial cancer cells. | 2010 Jun |
1 |
| 137 |
20716641 | TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation. | 2010 Oct |
1 |
| 138 |
19033425 | Antitumor effect in medulloblastoma cells by gefitinib: Ectopic HER2 overexpression enhances gefitinib effects in vivo. | 2009 Jun |
2 |
| 139 |
19150933 | Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer. | 2009 May |
1 |
| 140 |
19212642 | Gefitinib circumvents hypoxia-induced drug resistance by the modulation of HIF-1alpha. | 2009 Mar |
2 |
| 141 |
19233551 | Bisphosphonate zoledronic acid enhances the inhibitory effects of gefitinib on EGFR-mutated non-small cell lung carcinoma cells. | 2009 Jun 8 |
1 |
| 142 |
19318229 | Growth inhibition by tyrosine kinase inhibitors in mesothelioma cell lines. | 2009 Jun |
1 |
| 143 |
19318490 | Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. | 2009 Apr 1 |
2 |
| 144 |
19371940 | Activated Akt prevents antitumor activity of gefitinib in renal cancer cells. | 2009 Jul |
10 |
| 145 |
19414346 | Pharmacological interplay between breast cancer resistance protein and gefitinib in epidermal growth factor receptor signaling. | 2009 Apr |
2 |
| 146 |
19483462 | Caveolin-1 regulates EGFR signaling in MCF-7 breast cancer cells and enhances gefitinib-induced tumor cell inhibition. | 2009 Aug |
1 |
| 147 |
19706799 | Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. | 2009 Sep 1 |
1 |
| 148 |
19898796 | Gefitinib induces apoptosis and decreases telomerase activity in MDA-MB-231 human breast cancer cells. | 2009 Oct |
1 |
| 149 |
17902048 | Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib ('Iressa') response and resistance. | 2008 Sep |
1 |
| 150 |
17910952 | EGFR and beta1 integrins utilize different signaling pathways to activate Akt. | 2008 Jan 15 |
1 |