Title : Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition.

Pub. Date : 2013 Jun

PMID : 23200321






2 Functional Relationships(s)
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1 In resistant cell lines harboring PIK3CA mutations, a PI3K inhibitor, LY294002, or AKT siRNA reduced cell viability with an additive effect demonstrated in combination with gefitinib. Gefitinib AKT serine/threonine kinase 1 Homo sapiens
2 Taken together this suggests that constitutively active AKT is a mechanism of intrinsic gefitinib resistance in SCCHN. Gefitinib AKT serine/threonine kinase 1 Homo sapiens