Temozolomide

tumor protein p53 ; Homo sapiens







100 Article(s)
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1 34937948 Correction: Lithium enhances the antitumour effect of temozolomide against TP53 wild-type glioblastoma cells via NFAT1/FasL signaling. 2022 Mar 1
2 34964241 Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy. 2022 Feb 1
3 35053532 Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin. 2022 Jan 12 1
4 35144430 Combining apatinib and temozolomide for brainstem glioblastoma: a case report and review of literature. 2022 Jan 1
5 32705436 HIF1α and p53 Regulated MED30, a Mediator Complex Subunit, is Involved in Regulation of Glioblastoma Pathogenesis and Temozolomide Resistance. 2021 Oct 1
6 33691199 Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner. 2021 Apr 23 2
7 34044759 miR-29a sensitizes the response of glioma cells to temozolomide by modulating the P53/MDM2 feedback loop. 2021 May 27 2
8 34072831 NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition. 2021 May 31 4
9 34253592 Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses. 2021 Oct 1
10 34539842 Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide. 2021 Nov 1
11 34660288 Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. 2021 3
12 34733363 Temozolomide abrogates the aggressiveness of urothelial carcinoma cells by enhancing senescence and depleting the side population. 2021 Dec 1
13 32296580 Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent signaling pathway. 2020 Feb 15 1
14 32666844 Evaluation of frequency magnetic field, static field, and Temozolomide on viability, free radical production and gene expression (p53) in the human glioblastoma cell line (A172). 2020 Oct 1 4
15 32785787 Comparative molecular analysis of primary and recurrent oligodendroglioma that acquired imbalanced 1p/19q codeletion and TP53 mutation: a case report. 2020 Dec 2
16 32878802 Temozolomide and AZD7762 Induce Synergistic Cytotoxicity Effects on Human Glioma Cells. 2020 Sep 2
17 30361254 Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR-CHK1, p21, and NF-κB. 2019 Jan 1 1
18 30536898 Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma. 2019 Jun 15 1
19 30664150 Synergistic anticancer effect of acteoside and temozolomide-based glioblastoma chemotherapy. 2019 Mar 1
20 30796178 The SIAH1-HIPK2-p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death. 2019 May 5
21 30925722 Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide? 2019 Mar 28 1
22 30940658 Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma. 2019 May 15 3
23 31081046 Targeted therapy based on p53 reactivation reduces both glioblastoma cell growth and resistance to temozolomide. 2019 Jun 3
24 31190889 Artificial microenvironment of in vitro glioblastoma cell cultures changes profile of miRNAs related to tumor drug resistance. 2019 1
25 31534534 MTBP regulates cell survival and therapeutic sensitivity in TP53 wildtype glioblastomas. 2019 1
26 29334602 High-Dose Metformin Plus Temozolomide Shows Increased Anti-tumor Effects in Glioblastoma In Vitro and In Vivo Compared with Monotherapy. 2018 Oct 1
27 29416795 Treatment-associated TP53 DNA-binding domain missense mutations in the pathogenesis of secondary gliosarcoma. 2018 Jan 5 4
28 29749471 GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells. 2018 Aug 4
29 30050935 Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest. 2018 3
30 27177180 Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist. 2017 Feb 2
31 27651340 The Correlation Between 1p/19q Codeletion, IDH1 Mutation, p53 Overexpression and Their Prognostic Roles in 41 Turkish Anaplastic Oligodendroglioma Patients. 2017 1
32 27888811 The role of p53 in cancer drug resistance and targeted chemotherapy. 2017 Jan 31 1
33 28147244 The PI3K inhibitor GDC-0941 enhances radiosensitization and reduces chemoresistance to temozolomide in GBM cell lines. 2017 Mar 27 1
34 28232952 Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer. 2017 1
35 28427200 IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway. 2017 Apr 25 1
36 28726196 Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide. 2017 Jun 1
37 28821714 GADD45A plays a protective role against temozolomide treatment in glioblastoma cells. 2017 Aug 18 3
38 26498391 Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation. 2016 Jan 1
39 27777210 [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells]. 2016 Oct 20 1
40 28000777 BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53. 2016 Dec 21 3
41 25240597 A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme. 2015 Feb 3
42 25625235 p53 upregulated modulator of apoptosis sensitizes drug-resistant U251 glioblastoma stem cells to temozolomide through enhanced apoptosis. 2015 Jun 2
43 25681668 The synergistic effect of combination temozolomide and chloroquine treatment is dependent on autophagy formation and p53 status in glioma cells. 2015 May 1 3
44 25808868 Decoy Receptor DcR1 Is Induced in a p50/Bcl3-Dependent Manner and Attenuates the Efficacy of Temozolomide. 2015 May 15 1
45 26428461 A stapled peptide antagonist of MDM2 carried by polymeric micelles sensitizes glioblastoma to temozolomide treatment through p53 activation. 2015 Nov 28 1
46 26553592 MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. 2015 2
47 26904387 Prediction of Response to Temozolomide in Low-Grade Glioma Patients Based on Tumor Size Dynamics and Genetic Characteristics. 2015 Dec 1
48 24248532 Gain of function of mutant TP53 in glioblastoma: prognosis and response to temozolomide. 2014 Apr 4
49 24453002 Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. 2014 Mar 15 1
50 24647572 ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy. 2014 May 15 1