Pub. Date : 2021
PMID : 34660288
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. | Temozolomide | tumor protein p53 | Homo sapiens |
| 2 | Our analysis of clinical data indicates that the survival benefit of a combined TMZ and VPA treatment in GBM patients is dependent on their p53 gene status. | Temozolomide | tumor protein p53 | Homo sapiens |
| 3 | In cellular experiments, our results show that VPA enhanced the antineoplastic effect of TMZ by enhancing p53 activation and promoting the expression of its downstream pro-apoptotic protein, PUMA. | Temozolomide | tumor protein p53 | Homo sapiens |