Title : Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma.

Pub. Date : 2019 Jun 15

PMID : 30536898






1 Functional Relationships(s)
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1 This is the first study to evaluate the in vivo efficacy of the intravenous idasanutlin prodrug, RO6839921 (RG7775), both alone and in combination with temozolomide in TP53 wt orthotopic neuroblastoma models. Temozolomide tumor protein p53 Homo sapiens