Pub. Date : 2018
PMID : 30050935
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As anticipated, TMZ caused DNA damage mediated by the ATM/p53/p21 signaling pathway and induced significant G2 delay. | Temozolomide | tumor protein p53 | Homo sapiens |
| 2 | Mechanistic study showed that coadministration of caffeine and TMZ suppressed the phosphorylation of ATM and p53 and downregulated p21 expression, thus releasing DNA-damaged cells from G2 arrest into premature mitosis. | Temozolomide | tumor protein p53 | Homo sapiens |
| 3 | In conclusion, our study demonstrated that caffeine enhanced the efficacy of TMZ through mitotic cell death by impeding ATM/p53/p21-mediated G2 arrest. | Temozolomide | tumor protein p53 | Homo sapiens |