Pub. Date : 2021 May 31
PMID : 34072831
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | BMX and TMZ cotreatment also upregulated WT-p53 mediated MGMT inhibition, thereby triggering the activation of caspase-3 and eventually leading to apoptosis in GBM-R cells. | Temozolomide | tumor protein p53 | Homo sapiens |
2 | In conclusion, BMX overcomes TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the beta-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition. | Temozolomide | tumor protein p53 | Homo sapiens |
3 | In conclusion, BMX overcomes TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the beta-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition. | Temozolomide | tumor protein p53 | Homo sapiens |
4 | These findings indicate a promising drug combination for precision personal treating of TMZ-resistant WT-p53 GBM cells. | Temozolomide | tumor protein p53 | Homo sapiens |