Title : NBM-BMX, an HDAC8 Inhibitor, Overcomes Temozolomide Resistance in Glioblastoma Multiforme by Downregulating the β-Catenin/c-Myc/SOX2 Pathway and Upregulating p53-Mediated MGMT Inhibition.

Pub. Date : 2021 May 31

PMID : 34072831






4 Functional Relationships(s)
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1 BMX and TMZ cotreatment also upregulated WT-p53 mediated MGMT inhibition, thereby triggering the activation of caspase-3 and eventually leading to apoptosis in GBM-R cells. Temozolomide tumor protein p53 Homo sapiens
2 In conclusion, BMX overcomes TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the beta-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition. Temozolomide tumor protein p53 Homo sapiens
3 In conclusion, BMX overcomes TMZ resistance by enhancing TMZ-mediated cytotoxic effect by downregulating the beta-catenin/c-Myc/SOX2 signaling pathway and upregulating WT-p53 mediated MGMT inhibition. Temozolomide tumor protein p53 Homo sapiens
4 These findings indicate a promising drug combination for precision personal treating of TMZ-resistant WT-p53 GBM cells. Temozolomide tumor protein p53 Homo sapiens