Pub. Date : 2016 Dec 21
PMID : 28000777
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACH1 Promotes Temozolomide Resistance in Glioblastoma through Antagonizing the Function of p53. | Temozolomide | tumor protein p53 | Homo sapiens |
| 2 | Further investigation revealed that BACH1 activation significantly enhanced the expression of MGMT, and depletion of p53 disrupted the effects of BACH1 on MGMT and temozolomide resistance. | Temozolomide | tumor protein p53 | Homo sapiens |
| 3 | Collectively, our findings identify a potential mechanism by which wild-type TP53 GBM cells develop resistance to temozolomide and suggest that targeting this pathway may be beneficial for overcoming resistance. | Temozolomide | tumor protein p53 | Homo sapiens |