Pub. Date : 2018 Jan 5
PMID : 29416795
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Whether temozolomide (TMZ)-induced mutagenesis of the TP53 DNA-binding domain (DBD) can drive the pathogenesis of gliosarcoma is unclear. | Temozolomide | tumor protein p53 | Homo sapiens |
| 2 | Whether temozolomide (TMZ)-induced mutagenesis of the TP53 DNA-binding domain (DBD) can drive the pathogenesis of gliosarcoma is unclear. | Temozolomide | tumor protein p53 | Homo sapiens |
| 3 | Ex vivo treatment of the GBM spheres with TMZ generated numerous variants in cancer driver genes, including TP53 and CDH1, which were mutated in the post-treatment tumor. | Temozolomide | tumor protein p53 | Homo sapiens |
| 4 | Conclusions: TMZ-induced TP53 gain-of-function mutations can have a driving role in secondary gliosarcoma pathogenesis. | Temozolomide | tumor protein p53 | Homo sapiens |