Pub. Date : 2015 Feb
PMID : 25240597
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | It was previously demonstrated that delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex (SGT-53) which crosses the blood-brain barrier could sensitize highly TMZ-resistant GBM tumors to TMZ. | Temozolomide | tumor protein p53 | Homo sapiens |
2 | It was previously demonstrated that delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex (SGT-53) which crosses the blood-brain barrier could sensitize highly TMZ-resistant GBM tumors to TMZ. | Temozolomide | tumor protein p53 | Homo sapiens |
3 | FROM THE CLINICAL EDITOR: Using human glioblastoma multiforma cell lines, this research team demonstrated that the delivery of exogenous wild-type tumor suppressor gene p53 via a tumor-targeted nanocomplex limited the development of temozolomide resistance and prolonged its anti-tumor effect, which may enable future human application of this or similar techniques. | Temozolomide | tumor protein p53 | Homo sapiens |