Title : The role of p53 in cancer drug resistance and targeted chemotherapy.

Pub. Date : 2017 Jan 31

PMID : 27888811






1 Functional Relationships(s)
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1 Overexpression of mutated p53 with reduced or abolished function is often connected to resistance to standard medications, including cisplatin, alkylating agents (temozolomide), anthracyclines, (doxorubicin), antimetabolites (gemcitabine), antiestrogenes (tamoxifen) and EGFR-inhibitors (cetuximab). Temozolomide tumor protein p53 Homo sapiens