Pub. Date : 2017 Aug 18
PMID : 28821714
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In MGMT-deficient/TMZ-sensitive cells (U87 and U373), GADD45Akd decreased TMZ-induced TP53 expression. | Temozolomide | tumor protein p53 | Homo sapiens |
| 2 | In MGMT-deficient/TMZ-sensitive cells (U87 and U373), GADD45Akd decreased TMZ-induced TP53 expression. | Temozolomide | tumor protein p53 | Homo sapiens |
| 3 | Thus, in this study, we investigated the genes influenced by TMZ that were important in GBM therapy, and revealed that GADD45A plays a protective role against TMZ treatment which may through TP53-dependent and MGMT-dependent pathway in TMZ-sensitive and TMZ-resistant GBM, respectively. | Temozolomide | tumor protein p53 | Homo sapiens |